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The average incubation period, which begins immediately after the initial sexual contact with an infected person, is usually two to three months but can range from one to 20 months. However, when HPV is transmitted from one person to another, the virus infects the top layers of the skin and can remain inactive or latent for months or possibly years before warts or other signs of HPV infection appear. In couples that have not had sex partners for many years, the woman may develop an abnormal Pap smear because of previous contact.